When highly acidic chyme enters the duodenum, which hormone stimulates the release of pancreatic secretions that contains very high bicarbonate ion content? Explain your answer.
a. Gastrin
b. Secretin
c. Cholecystokinin
d. Histamine
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b. Secretin
Secretin is the hormone that stimulates the release of pancreatic secretions with a high bicarbonate ion content when highly acidic chyme enters the duodenum. This hormone is produced by specialized cells in the lining of the duodenum in response to the presence of acidic chyme. Secretin then enters the bloodstream and travels to the exocrine pancreas, where it stimulates the pancreas to release bicarbonate ions into the duodenum. Bicarbonate ions raise the pH of the chyme, making it less acidic and creating a more favorable environment for digestion to continue.
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