Determine the molar amount of an active pharmaceutical ingredient (API) required to prepare 100,000 tablets, each containing 50 mg of the API.
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To determine the molar amount of an active pharmaceutical ingredient (API) required to prepare 100,000 tablets, each containing 50 mg of the API, we will follow these steps:
1. Convert the tablet weight from milligrams (mg) to grams (g):
50 mg = 50/1000 g
= 0.05 g
2. Determine the total weight of the API required for 100,000 tablets:
Total weight = number of tablets x tablet weight
= 100,000 tablets x 0.05 g
= 5,000 g
3. Calculate the molar mass of the API. This can be found on the chemical structure or by looking up the molecular formula in a periodic table or online database.
4. Convert the total weight of the API to moles:
Moles = mass of API / molar mass of API
= 5000 g / molar mass of API
Remember to use the correct unit conversion factors and ensure consistent units throughout the calculation.
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